:root{--bg:#f3f5f8;--ink:#1b2d3e;--muted:#68798b;--line:#dbe3eb;--blue:#2267aa;--green:#368775;--red:#ce725e;--mono:ui-monospace,SFMono-Regular,Consolas,monospace}
*{box-sizing:border-box}body{margin:0;background:var(--bg);color:var(--ink);font:14px -apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif}button,input,select{font:inherit}button,a,input,select{outline-offset:3px}button{cursor:pointer;border:1px solid var(--line);border-radius:6px;background:#fff;color:var(--ink);padding:9px 12px}button:hover{border-color:#91acc4;background:#f5f9fc}button:disabled{opacity:.45;cursor:default}input,select{border:1px solid #cfd9e3;background:white;border-radius:5px;padding:9px 10px;color:var(--ink);min-width:0}a{color:var(--blue);text-decoration:none}header{height:78px;padding:0 28px;display:flex;align-items:center;gap:40px;background:white;border-bottom:1px solid var(--line)}.brand{display:flex;gap:12px;align-items:center;color:var(--ink)}.brand b{font-size:18px;font-weight:650;letter-spacing:-.5px}.brand small{display:block;font-size:11px;color:var(--muted);margin-top:5px}.brand-icon{border:1px solid #97b4cd;background:#eff6fc;border-radius:50%;width:36px;height:36px;text-align:center;line-height:35px;color:var(--blue);font-weight:700}nav{display:flex;align-items:center;gap:24px;flex:1}nav a{color:var(--muted)}.nav-active{font-weight:600;color:var(--blue)}.pill{font-size:11px;background:#eff5f9;border:1px solid var(--line);padding:7px 10px;border-radius:20px;color:var(--muted)}main{display:grid;grid-template-columns:290px minmax(0,1fr);min-height:calc(100vh - 78px)}aside{padding:27px 20px;background:#fafbfd;border-right:1px solid var(--line)}.eyebrow{font:10px var(--mono);letter-spacing:1.6px;color:var(--muted);font-weight:600}h1{font-size:27px;font-weight:600;line-height:1.2;letter-spacing:-.8px;margin:14px 0}h2{font-size:19px;letter-spacing:-.4px;margin:8px 0}h3{font-size:15px;margin:12px 0}.muted{color:var(--muted);font-size:12px;line-height:1.65}.search-label{display:block;margin:23px 0 8px;font-size:11px;font-weight:600}#sample-search,#clade-filter{width:100%;margin-bottom:8px}.catalog-count{font:10px var(--mono);color:var(--muted);margin:16px 0 10px}#sample-list{max-height:calc(100vh - 440px);min-height:230px;overflow:auto}.sample{padding:12px 8px;border-bottom:1px solid #e5ebf1;display:flex;gap:7px;align-items:center}.sample-info{flex:1;min-width:0}.sample b{font-size:12px;display:block;font-style:italic;font-weight:600}.sample small{display:block;color:var(--muted);font:10px var(--mono);margin-top:5px}.sample .annotation-tag{font:10px sans-serif;color:var(--green)}.sample button{padding:3px 8px;font-size:16px}.aside-footer{margin-top:22px;color:var(--muted);font-size:10px;line-height:2}.dot{width:7px;height:7px;display:inline-block;border-radius:50%;margin-right:3px}.positive{background:var(--blue)}.negative{background:var(--red);margin-left:8px}.workspace{padding:24px 26px;max-width:1800px;min-width:0}.query-panel,.visual-panel,.details-panel{background:white;border:1px solid var(--line);border-radius:9px}.query-panel{padding:23px}.panel-heading{display:flex;align-items:center;justify-content:space-between;gap:15px}.mode-switch,.view-tabs{display:flex;gap:4px}.mode-switch{background:#f0f4f8;padding:4px;border-radius:7px}.mode-switch button{font-size:11px;border:0;background:transparent;padding:8px 10px}.mode-switch .active,.view-tabs .active{background:#eaf2fa;color:var(--blue);font-weight:600}.region{display:grid;grid-template-columns:minmax(165px,1.1fr) minmax(160px,1.1fr) 105px 105px auto;align-items:center;gap:8px;padding:12px 0;border-top:1px solid #e7edf2}.region-name b{display:block;font-size:12px;font-style:italic}.region-name small{display:block;color:var(--muted);font:10px var(--mono);margin-top:5px}.region select,.region input{font:11px var(--mono);width:100%}.region label{font-size:10px;color:var(--muted);display:grid;gap:4px}.region-buttons{display:flex;gap:3px;padding-top:16px}.region-buttons button{padding:6px;font-size:11px}.query-controls{display:flex;align-items:flex-end;gap:14px;flex-wrap:wrap;border-top:1px solid var(--line);padding-top:17px;margin-top:8px}.query-controls label{position:relative;display:grid;gap:7px;font-size:10px;color:var(--muted)}.query-controls input{width:112px;padding-right:28px}.query-controls select{font-size:12px}.input-note{position:absolute;right:10px;bottom:12px;font-size:10px}.primary{background:var(--blue);color:white;border-color:var(--blue);margin-left:auto;padding:11px 16px}.primary:hover{background:#18578f;color:white}.coordinate-note{font-size:10px;color:var(--muted);margin:14px 0 0;line-height:1.6}#status{padding:14px 2px;font-size:12px;color:var(--muted);line-height:1.6}#status.error{color:#a33d31}#status.loading{color:var(--blue)}.view-toolbar{border-bottom:1px solid var(--line);padding:12px 17px;display:flex;align-items:center;justify-content:space-between;gap:14px;flex-wrap:wrap}.view-tabs button{border:0;font-size:12px}.view-actions{display:flex;gap:10px;align-items:center;font-size:11px;color:var(--muted)}.view-actions button{font-size:10px;padding:7px}.visual-heading{padding:20px 23px 8px;display:flex;align-items:center;justify-content:space-between}.visual-heading p{margin-top:5px}#result-stats{font:11px var(--mono);color:var(--muted);text-align:right;line-height:1.8}.empty-view{text-align:center;padding:70px 10px;color:var(--muted);font-size:12px;line-height:1.8}.empty-symbol{font:36px var(--mono);color:#91aac1}#visualization{overflow:auto;padding:8px 16px 18px}#visualization svg{width:100%;display:block;min-width:600px}svg text{font-family:var(--mono);fill:var(--muted);font-size:10px}.ribbon{cursor:pointer;opacity:.23;stroke-width:.6}.ribbon:hover,.ribbon.selected{opacity:.65;stroke:var(--ink);stroke-width:1}.gene{fill:var(--green);cursor:pointer}.gene:hover{fill:#164e43}.axis{stroke:#bdcbd8;stroke-width:1}.gridline{stroke:#e8eef4;stroke-width:1}.track-label{fill:var(--ink);font-size:11px;font-weight:600}.annotation-label{font-size:9px}.visual-footer{padding:12px 20px;border-top:1px solid var(--line);color:var(--muted);font-size:10px;display:flex;justify-content:space-between;gap:15px}.details-panel{padding:20px 23px;margin-top:18px}#details dl{display:grid;grid-template-columns:160px 1fr;gap:10px;font-size:12px}#details dt{color:var(--muted)}#details dd{margin:0;font-family:var(--mono);overflow-wrap:anywhere}#details .source-detail{font-size:10px}.target-chip{display:inline-flex;align-items:center;gap:10px;margin:5px;padding:8px 11px;background:#eef4f9;border-radius:6px;font-size:12px}.target-chip button{border:0;background:none;padding:0}#pair-picker{padding:0 23px 10px}#pair-picker select{max-width:100%;font-size:12px}.dot-segment{stroke-width:2;cursor:pointer}.dot-segment:hover{stroke-width:5}.result-region{cursor:pointer}.result-region:hover{fill:var(--blue)}.notice{font-size:11px;color:#9a6a20}.fatal-overlay{padding:35px;border:1px solid #e9c4bb;background:#fff7f4;border-radius:8px;line-height:1.7;color:#8d3c2d}.fatal-overlay code{font-family:var(--mono);font-size:12px}#target-list p{font-size:12px;color:var(--muted)}
@media(max-width:1100px){main{grid-template-columns:240px minmax(0,1fr)}.workspace{padding:16px}.query-panel{padding:16px}.panel-heading{align-items:flex-start;flex-direction:column}.region{grid-template-columns:1fr 1fr 90px 90px}.region-buttons{grid-column:1/-1;padding-top:0}.primary{margin-left:0}header{gap:20px;padding:0 18px}nav{gap:15px;font-size:12px}}
@media(max-width:760px){header{height:auto;min-height:78px;flex-wrap:wrap;padding:14px;gap:14px}.brand small{display:none}nav{order:3;flex-basis:100%}main{display:block}aside{border-right:0;border-bottom:1px solid var(--line);padding:20px}aside h1,aside>.muted,.aside-footer{display:none}.search-label{margin-top:14px}#sample-list{max-height:200px;min-height:0}.workspace{padding:12px}.region{grid-template-columns:1fr 1fr}.region-name{grid-column:1/-1}.region-buttons{grid-column:auto}.query-controls{gap:10px}.visual-heading{padding:16px;align-items:flex-start}.visual-footer{flex-direction:column}.view-actions{flex-wrap:wrap}#details dl{grid-template-columns:105px 1fr}.pill{margin-left:auto}}
.connection-panel{display:flex;gap:15px;align-items:center;justify-content:space-between;border:1px solid var(--line);border-radius:8px;background:#edf4fa;padding:15px 20px;margin-bottom:15px}.connection-panel b{font-size:12px}.connection-panel p{font-size:11px;color:var(--muted);line-height:1.6;margin:5px 0 0;max-width:480px}.connection-controls{display:flex;gap:7px;flex-wrap:wrap;align-items:center}.connection-controls input{width:210px;font-size:11px}.connection-controls button{font-size:11px;white-space:nowrap}.connection-panel.preview-mode{background:#fff8ea;border-color:#e9dbb8}.snapshot-notice{color:#896523!important;font-weight:600}@media(max-width:1100px){.connection-panel{align-items:flex-start;flex-direction:column}}@media(max-width:760px){.connection-controls input{width:100%}.connection-controls{width:100%}}